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Review Article
2021
:2;
12
doi:
10.25259/JRHM_51_2020

Transmissibility: To be or not to be

Independent Researcher, 1/8A, Mohendra Banerjee Road, Kolkata, West Bengal, India
Kolkata Global IVF Clinic, Kolkata, West Bengal, India
Kolkata Global IVF Clinic and Gynae Care Fertility Clinic, Kolkata, West Bengal, India
Department of Sociology, Dr. A.P.J. Abdul Kalam Government College, Kolkata, West Bengal, India
Indian Council of Medical Research, New Delhi, India
Department of Anthropology, Sikkim University, Gangtok, Sikkim, India
Corresponding author: Amlan Kanti Ray, Independent Researcher, 1/8A, Mohendra Banerjee Road, Kolkata - 700060, West Bengal, India. Email: humanedestiny@gmail.com
Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
How to cite this article: Ray AK, Das MC, Roychoudhury M, Das S, Bakshi S, Mondal N.. Transmissibility: To be or not to be. J Reprod Healthc and Med 2021;2:12.

Abstract

Appraising SARS-CoV-2 virus under the taxonomy category of coronaviridae family, which has been responsible for more than two million fatalities across the globe. It not only jeopardizes the normal life, but also potentiating the evolutionary progress towards a more lethal form. The lethal form, albeit is a bit virulent, is likely to predominate, thereby causing cumulative damage in any cluster that cannot even combat the wide spectrum of genetic variation. The impact on the vertical COVID-19 transmissibility of antenatal population is still sketchy about “nosocomial transmission” and the measures crude. The paper has reviewed the placental pathological findings of pregnant women afflicted with SARS-CoV-2 including the information, gathered from the subsequent stages of gestational outcomes. The possibility of the vertical transmission of SARS-CoV-2 due to the probable placental barrier damage caused by the severe maternal hypoxia, Homo sapiens (human) angiotensin-converting enzyme-2 (hACE2) influenced transplacental migration of SARS-CoV-2 in advanced gestational age, the plausible presence of RNAemia (detection of SARS-CoV-2 in the blood) in hematogenous route was reviewed in this paper. Nevertheless, the probability of susceptible intrauterine or perinatal infection of fetus does not conclusively decide as chances of involving placental coexpression of hACE2 and transmembrane protease, serine 2 in cytoplasmic entry of SARS-CoV-2 remains insignificant, exhibiting the probable relative insensitivity to transplacental infection. The present paper will provide an important insight about the wider understanding of the SARS-CoV-2 pathogenesis in the placenta that canvassed across all trimesters of pregnancy in response to the indiscriminate spread across globe at the time of therapeutic interventions.

Keywords

SARS-CoV-2
Human angiotensin-converting enzyme 2
RNAemia
Placenta
Breast milk

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